Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics

• 收藏
• 分享

专利权人:

Salk Institute for Biological Studies

发明人:

Clodagh O'Shea,William Partlo,Colin Powers

申请号：

US16110207

公开号：

US10738325B2

申请日:

2018.08.23

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Recombinant adenovirus genomes that include an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. Optimal placement of the exogenous genes for minimal impact on viral kinetics is further disclosed. Therapeutic applications of the recombinant adenoviruses are also described.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/