GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH CHINESE ACADEMY OF SCIENCES
发明人:
Jinyong WANG,Rongqun GUO,Mengyun ZHANG,Lijuan LIU,Xiaofei LIU,Cui LV,Juan DU
申请号：
US16312794
公开号：
US20200208107A1
申请日:
2018.01.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides a pluripotent stein cell comprising a co-expression vector in which Runx1 and Hoxa9 are of in tandem, and a T cell differentiated therefrom and application thereof. In the present invention, Pluripotent stein cells inducibly co-expressing exogenous Runx1 and Hoxa9 are successfully established by introducing an exogenous vector co-expressing Runx1 and Hoxa9 into pluripotent stein cells. The pluripotent stein cells are directionally differentiated into T-lineage progenitor cells and will be developed into T cells. The pluripotent stein cell-derived T cells obtained by the method of the present invention are not only functionally normal but also have no tumorigenic risk.
