The present invention is directed to pyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.本發明係關於嘧啶化合物，其可用作治療與磷酸二酯酶10(PDE10)相關之中樞神經系統病症的治療劑。本發明亦係關於該等化合物之用途，其用於治療神經及精神病症，例如精神分裂症、精神病或亨廷頓氏病(Huntington's disease)，以及彼等與紋狀體功能不良或基底神經節功能障礙相關之病症。
