Use what to prevent and treat associated disease and as the diaryl of 5-HT2A serotonin receptor modulator and aryl heteroaryl urea derivative

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专利权人:

艾尼納製藥公司;Arena Pharmaceuticals; Inc.;Arena Pharmaceuticals, Inc.;艾尼纳制药公司

发明人:

布拉德利．特加登,洪纳帕．贾亚库马尔,洪納帕．賈亞庫馬爾,李红梅,李紅梅,索尼娅．斯特拉－普莱内特,索尼婭．斯特拉－普萊內特,彼得．伊恩．多萨,彼得．伊恩．多薩,布拉德利.特加登,洪纳帕.贾亚库马尔,洪納帕.賈亞庫馬爾,索尼娅.斯特拉-普莱内特,索尼婭.斯特拉-普萊內特,彼得.伊恩.多萨,彼得.伊恩.多薩

申请号：

MOJ000793

公开号：

MOJ000793B

申请日:

2012.06.05

申请国别(地区):

MO

年份:

2012

代理人:

摘要：

The present invention relates to certain pyrazole derivatives of formula (I) and its medical composition, adjust the activity of 5-HT2A serotonin receptor. Compound and its medical composition are directed to method what prevention or treat following disease: platelet aggregation,Coronary artery disease,Myocardial infarction,Temporal cerebral ischemia seizure,Angina pectoris,Apoplexy,Atrial fibrillation,The risk of reduction thrombosis,Asthma or its symptom,Restless or symptom,Behavior illness,Drug-induced mental disease,Excited type mental disease,Du Leiteshi syndrome,Emotional conditions,Organic or NOS mental disease,Mental illness,Mental disease,Acute schizophrenia,Chronic schizophrenia,NOS schizophrenia and associated disease and sleep disorder,Sleep disorder,Diabetes related disorders disease similar with its. The present invention also relates to combine, be separately or concurrently administered to prevent or treat the method that 5-HT2A serotonin receptor adjusts illness with the dopamine D 2 receptor antagonist of such as haloperidol (haloperidol).本發明涉及式(I)的某些吡唑衍生物與其醫藥組合物，其調節5-HT2A血清素受體的活性。化合物與其醫藥組合物針對用於預防或治療下列疾病的方法：血小板凝集、冠狀動脉疾病、心肌梗塞、暫時性腦缺血發作、心絞痛、中風、心房纖維顫動、减小血栓形成的風險、哮喘或其症狀、躁動或症狀、行爲病症、藥物誘發的精神病、興奮型精神病、杜雷特氏症候群、情緒病症、器質性或NOS精神病、精神病症、精神病、急性精神分裂症、慢性精神分裂症、NOS精神分裂症和相關病症以及睡眠病症、睡眠病症、糖尿病相關病症與其類似疾病。本發明也涉及與例如氟哌啶醇(haloperidol)的多巴胺D2 受體拮抗劑組合、分別或同時給藥 以預防或治療5-HT2A血清素受體調節病症的方法。

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/