1. A pharmaceutical composition suitable for oral administration that consists of a mixture of:! (i) compounds of formula I:! ! in which R is selected from hydrogen, halogen, trifluoromethyl, C1-6 alkyl or C3-7 cycloalkyl； ! X represents oxygen (—O—) or methylene (—CH 2 -)； ! R 2 and R 3 are the same or different and are halogen or C 1-4 alkyl； ! R4 is hydrogen or C1-4 alkyl； ! R5 is hydrogen or C1-4 alkyl； and! R6 represents hydrogen or an alkanoyl or aroyl group, or another group capable of bioconversion to obtain a free phenolic structure in which R6 = H； ! or a pharmaceutically acceptable salt or ester or solvate thereof； ! (ii) a pharmaceutically acceptable particulate base solid； and! (iii) optionally one or more additional pharmaceutical excipients,! where component (ii) is at least 1 wt.% the mixture. ! 2. The composition according to claim 1, in which component (ii) is at least 40 wt.% The mixture. ! 3. The composition according to claim 1, in which the pharmaceutically acceptable basic solids in the form of particles comprise at least 70 wt.% The mixture. ! 4. The composition according to claim 1, in which the mixture is essentially free of any fillers other than basic solids in the form of particles. ! 5. The composition according to claim 1, in which component (i) is ground. ! 6. The composition according to claim 1, in which component (iii) contains one or more binders, a dispersant and a sizing. ! 7. The composition according to claim 6, in which the binder is maltodextrin； the dispersant is carboxymethylated cellulose, carboxymethyl starch or starch1. Фармацевтическая композиция, подходящая для перорального введения, которая состоит из смеси: ! (i) соединения формулы I: ! ! в которой R выбран из водорода, галогена, трифторметила, С1-6алкила или С3-7циклоалкила； ! Х представляет собой кислород (-О-) или метилен (-СН2-)； ! R2 и R3 являются одинаковыми или разными и представляют собой галоген или С1-4алкил； ! R4 представляет собой водород или С1
