ВЕРВЕЙС Маринус Якобус (US),КАРКАРЕ Радхика (US),МУР Майкл Дуглас (US)
申请号：
RU2015120798
公开号：
RU2015120798A
申请日:
2013.11.01
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A pharmaceutical composition comprising a fixed dose of 3- (6- (1- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid (Compound 1) Form I and a solid dispersion comprising essentially amorphous N- (5-hydroxy-2,4-ditret-butyl-phenyl) -4-oxo-1H-quinoline-3-carboxamide (Compound 2) .2. The pharmaceutical composition according to claim 1, further comprising: a. filler； b. baking powder； c. surfactant； ig. a binder； called PC-I.3. The pharmaceutical composition according to claim 1, comprising from 30 to 55 percent by weight of Compound 1 of Form I and from 10 to 45 percent by weight of a solid dispersion comprising a substantially amorphous Compound 2.4. The pharmaceutical composition according to claim 2, having the following composition: called PC-II.5. A pharmaceutical composition comprising: a. Compound 1 of Form I； b. a solid dispersion comprising a substantially amorphous Compound 2； filler； g. baking powder； d. surfactant； e. a binder； Izh. lubricant； called PC-III.6. The pharmaceutical composition of claim 5, comprising from about 100 to 250 mg of Compound 1 of Form I and from about 80 to 150 mg of a substantially amorphous Compound 2.7. The pharmaceutical composition of claim 5, comprising about 200 mg of Compound 1 of Form I and about 125 mg of a substantially amorphous Compound 2.8. The pharmaceutical composition of claim 5, comprising about 200 mg of Compound 1 of Form I and about 83 mg of a substantially amorphous Compound 2.9. The pharmaceutical composition of claim 5, comprising approximately 150 mg of Compound 1 of Form I and approximately 125 mg of a substantially amorphous Compound 2.10. The pharmaceutical composition of claim 5, comprising from 25 to 50 percent by weight of Compound 1 of Form I and from about 15 to 35 percent by weight of solid1. Фармацевтическая композиция, включающая фиксированную величину дозы 3-(6-(1-(2,2-дифторбензо[d][1,3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-
