Foster, Keith,Chaddock, John,Penn, Charles,Aoki, K. Roger,Francis, Joseph,Steward, Lance
申请号：
AU2011202225
公开号：
AU2011202225A1
申请日:
2011.05.13
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011202225A120121129.pdf#####130 ABSTRACT Non-cytotoxic Protein Conjugates 5 A non-cytotoxic protein conjugate for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell, comprising: (i) a dynorphin Targeting Moiety (TM), wherein said TM is an agonist of a receptor present on said nociceptive sensory afferent cell, and wherein said receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell (ii) a non-cytotoxic 1o protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of said nociceptive sensory afferent cell and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory is afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described.
