Foster, Keith,Chaddock, John,Penn, Charles,Aoki, K. Roger,Francis, Joseph,Steward, Lance
申请号：
AU2011244911
公开号：
AU2011244911B2
申请日:
2011.11.01
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2011244911B220130606.pdf#####ABSTRACT The invention relates to a non-cytotoxic protein conjugate for inhibition or 5 reduction of exocytic fusion in a nociceptive sensory afferent cell, comprising: (i) Targeting Moiety (TM), wherein said TM is an agonist of a receptor present on said nociceptive sensory afferent cell, and wherein said receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell； (ii) a non-cytotoxic protease or a fragment thereof, io wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of said nociceptive sensory afferent cell； and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent 15 cell, wherein the TM and the translocation domain are separated by a spacer having an amino acid sequence of 20-29 amino acid residues. 2907462_1 (GHMatters) P73912.AU.2 31/10111
