Control of virus-based replicon gene expression using aptamers

• 收藏
• 分享

专利权人:

Novartis AG

发明人:

Bell, Christie,Yu, Dong,Mason, Peter,Beard, Clayton

申请号：

AU2014101350

公开号：

AU2014101350A4

申请日:

2014.11.11

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

#$%^&*AU2014101350A420141211.pdf#####- 16ABSTRACT The invention provides, inter alia, isolated nucleic acid molecules encoding a positive strand self-replicating RNA and further comprising at least two heterologous small moleculeresponsive aptamers. In related aspects, the invention also provides methods of controllably regulating gene expression (e.g., of an immunogen) by modulating the levels of the small molecule to which the small molecule-responsive aptamer binds.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/