MORALES MERCEDES,IMRAN MIR,KORUPOLU RADHIKA,HASHIM MIR
申请号：
IN201617042019
公开号：
IN201617042019A
申请日:
2016.12.08
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin incretins and immunoglobulins such as TNF inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.
