A bottle support shoe receives a closed end of a medicine bottle to stabilize and inhibit slippage of a medicine bottle, and to hold the bottle upright. The shoe comprises a plate having a superior face defined by a convex shape that creates suction, and a mount face defined by a concave shape that creates suction. An interior sidewall extends from the plate at an angle between 44 degrees to 110 degrees, such that engaging the superior face with the closed end of bottle creates air space between the interior sidewall and the superior face. Engaging the mount face with a ground surface decreases and maintains air space between the interior sidewall and the mount face. An exterior sidewall circumambulates the interior sidewall. A bridge extends from interior sidewall to exterior sidewall. A grip panel overlays the mount face to further prevent slippage of the shoe.
