A urine collection system includes a collection element configured for operable connection to a catheter for accumulating urine expelled from a subject and defining an opening for passage of the urine from the collection element and a drainage device extending from the collection element and positioned about the opening in the collection element. The drainage device includes a drain spout defining an outlet port disposed above the opening in the collection element. Urine collected in the collection element exits the opening within the collection element to be drained through the outlet port of the drain spout until the volume of urine reaches a predetermined level below the outlet port. Upon reaching the predetermined level, the urine remaining within the drainage device establishes a fluid trap substantially preventing contaminants from entering the collection element through the opening.