The invention generally relates to guidewires for intravascular procedures that include an electroactive polymer. An electroactive polymer can be at one or a number of locations on or within a guidewire. The polymer reacts to an applied electrical potential by changing a dimension (e.g., contracting or expanding). Electroactive polymers can be disposed along or within the guidewires in any pattern, such as wrapped helically within a surface, placed longitudinally parallel to an axis of the guidewire, dispose circumferentially around the guidewire, others, or a combination thereof. Depending on the designed geometry, a potential difference applied by an actuator will cause the guidewire to change a shape, a property, a surface characteristic, a dimension, or a combination thereof.