ANDERSSON, SVEN-BORJE,BERGENGREN, GUNNAR,BOSSON, BENGT,HUGERTH, ANDREAS,NICKLASSON, FREDRIK,OLSSON, ROLAND
申请号：
NZ58073108
公开号：
NZ580731A
申请日:
2008.04.21
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a coated pharmaceutical product for intraoral delivery of nicotine comprising at least one buffered or non-buffered core, nicotine in any forn and/or a nicotine mimicking agent selected from one or more of capsaicin, piperine and zingerone, at least one coating layer and optionally one or more other additive(s), wherein said at least one coating layer comprises a buffering agent comprising at least one amino acid selected from the group consisting of Arginine, Aspargine, Glutamic acid, Glutamine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Serine, Threonine, Valine, Cysteic acid, N-Glycylglycine and Ornithine, and salts of any of the foregoing, and wherein the product further comprises a pH-adjusting compound when the pH-adjusting capacity of said at least one amino acid and/or a salt thereof is insufficient to increase the pH of the saliva of a subject to whom the product is administered to at least about 7. Further disclosed is the use of said product in the preparation of a medicament for delivering nicotine in any form to a subject, wherein the medicament is for oral administration such that the nicotine is released in the saliva in the oral cavity and absorbed into the systemic circulation of the subject. Also disclosed is a system for delivering nicotine in any form to a subject, comprising said coated product and at least one other product for obtaining reduction of the urge to smoke or use tobacco. Also disclosed is a method for producing said coated product, wherein the product is a chewing gum or a tablet. Also disclosed is the use of said product for use in the treatment of nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.
