AEBI, JOHANNES,AMREIN, KURT,CHEN, WENMING,HORNSPERGER, BENOIT,KUHN, BERND,LIU, YONGFU,MAERKI, HANS P.,MAYWEG, ALEXANDER V,MOHR, PETER,TAN, XUEFEI,WANG, ZHANGUO,ZHOU, MINGWEI
申请号:
PH12014501179
公开号:
PH12014501179A1
申请日:
2014.05.26
申请国别(地区):
PH
年份:
2014
代理人:
摘要:
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as described herein,compositions including the compounds and methods of using the compounds as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrom.