A disinfecting connector of a dialysis system, including: a disinfecting chamber positioned within an internal lumen of the disinfecting connector, including: at least one barrier between the internal lumen and a tube connected to the disinfecting connector； a disinfecting material that is approved for usage inside the body； wherein penetration of a second connector through the at least one barrier causes or allows flow of said disinfecting material into the second connector in an amount and surface coverage sufficient disinfects a flow path between the second connector and the tube.
