The present invention relates to a therapeutic knee brace system including a leg brace for support, a retainer for securing the therapeutic knee brace system to a knee joint therapy site, a brace joint providing a limited range of flexion to the knee brace, and an active thermal exchange bladder coupled to a contrast therapy system for delivering a therapy fluid at a select temperature, pressure and rate. Thermal exchange bladder is removable, and the pressure may be constant or dynamic. The angle of flexion may be selected by the therapy recipient, and the range of flexion of the brace joint is configurable. The knee brace may communicate range and instant angle of flexion of the brace joint to a continuous passive motion (CPM) device, and communication may be mechanical, electronic or wireless. A knee brace coupler attaches to a CPM coupler on the CPM device to selectively couple the therapeutic knee brace system to the CPM device.