BRUNKOW MARY E.,GALAS DAVID J.,KOVACEVICH BRIAN,MULLIGAN JOHN T.,PAEPER BRYAN W.,VAN NESS JEFFREY,WINKLER DAVID G.,BRUNKOW Mary E.,GALAS David J.,KOVACEVICH Brian,MULLIGAN John T.,PAEPER Bryan W.,VAN NESS Jeffrey,WINK
申请号：
SI200432101
公开号：
SI1638999T1
申请日:
2004.06.15
申请国别(地区):
SI
年份:
2013
代理人:
摘要：
The invention relates to an antibody, or antigen-binding fragment thereof, that binds specifically to a sclerostin polypeptide. The antibody or antigen-binding fragment is useful for increasing bone mineral content and/or bone mineral density in a warm-blooded animal or human, for example in the treatment of conditions such as osteopenia, osteoporosis, a fracture, achondroplasia, cleidrocranial dysostosis, echondromatosis, fibrous dysplasia, Gaucher's Disease, hypophoshatemic rickets, Marfan's syndrome, multiple hereditary exotoses, neurofibromatosis, osteogenesis inperfecta, osteopetrosis, osteopoikilosis, sclerotic lesions, peridontal disease, pseudoarthosis and pyogenic osteolmyelitis.
