The present invention relates to a drug delivery device for injecting a dose of a medicament, comprising of a cartridge holder adapted to house a cartridge filled with the medicament and comprising a displaceable piston, a body adapted to house a drive mechanism comprising a piston rod to be operably engaged with the piston of the cartridge for expelling a dose of the medicament, wherein the cartridge holder and the body are interconnected with each other and wherein the cartridge holder and/or the body comprise at least one separate fractionizing piece irreversibly detachable from the cartridge holder and/or from the body to irreversibly abrogate the interconnection of cartridge holder and body.
