The present application relates to certain halo-substituted piperidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.本申請案係關於某些經鹵素取代之六氫吡啶化合物、含有其等之醫藥組合物及其等使用方法,包括用於治療物質成癮、恐慌症、焦慮症、創傷後壓力病症、疼痛、抑鬱症、季節性情感障礙、飲食障礙或高血壓之方法。