Normalization of the enterohepatic circulation in animals with a chimeric humanized liver

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专利权人:

Markus Grompe;Willscott Naugler

发明人:

Markus Grompe,Willscott Naugler

申请号：

US14529011

公开号：

US09566315B2

申请日:

2014.10.30

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Methods of normalizing bile acid production in a mouse engrafted with human hepatocytes by the administration of human FGF19 are disclosed. Also disclosed is a transgenic host animal, such as a mouse, that expresses human FGF19 that has normalized bile acid production when engrafted with human hepatocytes.

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中国工程科技知识中心

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http://www.ckcest.cn/home/