A compound having the structure useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.高血圧、肺動脈性肺高血圧症(PAH)、鬱血性心不全、過度な水分貯留に起因する病状、心血管疾患、糖尿病、酸化的ストレス、内皮機能不全、肝硬変、子癇前症、骨粗鬆症またはネフロパシーの処置に有用な構造(I)を有する化合物。【化1】