HAM, YOUNG JINKR,함영진,SON, JUNG BEOMKR,손정범,PARK, CHANG HEEKR,박창희,KANG, SEOK JONGKR,강석종,CHOI, JAE YULKR,최재율,KIM, SEO HEEKR,김서희
申请号：
KR1020140194888
公开号：
KR1020160002318A
申请日:
2014.12.31
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a novel pyrimidine derivative compound having inhibitory activities with respect to TAK1 kinase, and to a pharmaceutical composition comprising the same for preventing or treating cancer or tumor. According to the present invention, pyrimidine derivatives in chemical formula 1 can be usefully used as a medicine or a prevention agent of cancer or tumor, with excellent inhibitory activities with respect to TAK1 kinase. The compound is selected from the pyrimidine derivatives in the chemical formula 1, pharmaceutically acceptable salt thereof, an optical isomer thereof, a hydrate thereof, and a solvate thereof.COPYRIGHT KIPO 2016본 발명은 TAK1 키나아제에 대한 저해 활성을 갖는 신규한 피리미딘 유도체 화합물 및 이를 포함하는 암 또는 종양의 예방 또는 치료용 약학적 조성물에 관한 것으로서, 본 발명에 따른 화학식 1의 피리미딘 유도체는 TAK1 키나아제에 대한 저해 활성이 우수하므로, 암 또는 종양의 예방 또는 치료제로서 유용하게 사용될 수 있다.
