2-ACÉTYL-6-(2-(2-(4-BROMOBENZYLIDEN)HYDRAZINYL) THIAZOL-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMÉTHYLDIBENZO[B,D]FURAN-1(9BH)-ONE, POSSÉDANT UN EFFET INHIBITEUR SUR LE FERMENT TYROSYL-ADN-PHOSPHODIESTÉRASE 1 DE L'HUMAIN
Obshestvo S Ogranichennoi Otvetstvennostju "Innovatie Pharmacology Research" (IPHAR)
发明人:
LUZINA, Olga Anatolyevna,ZAKHARENKO, Alexandra Leonidovna,SOKOLOV, Dmitry Nikolaevich,SALAKHUTDINOV, Nariman Faridovich,LAVRIK, Olga Ivanovna,KHAZANOV, Veniamin Abramovich
申请号：
EP17839910
公开号：
EP3498705A4
申请日:
2017.07.24
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to the field of molecular biology, biochemistry and biotechnology, namely, to compound 2-acetyl-6-(2-(2-(4-bromobenzylidene) hydrazinyl) thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1 (9bh)-one, which is a hydrazine-thiazole derivative of usnic acid of formula I and which is able to inhibit the action of human tyrosyl-DNA-phosphodiesterase 1 enzyme. Technical result: increase in inhibitory action towards human tyrosyl-DNA-phosphodiesterase 1 enzyme (Tdp1) and increase in the number of inhibitors of this enzyme.1 independent claim, 2 figures, 3 examples.
