Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.本文中所提供者為具有下列結構之雜芳基化合物：其中R1-R4均如本文定義，包含有效量之雜芳基化合物之組合物，及用於治療或預防癌症、炎性症狀、免疫學症狀、神經變性疾病、糖尿病、肥胖、神經病症、與老化有關聯之疾病或心血管症狀之方法，其包括對有需要之病患投予有效量之雜芳基化合物。
