An intrauterine system is disclosed for use in the treatment of dysfunctional uterine bleeding； menorraghia； dysmenorrhoea； endometriosis； uterine fibroids； climacteric complaints； osteoporosis； and urogenital atrophy. The system is formed by a frame defining an interior space for receipt of a deposit of a therapeutically effective dose of a biologically active compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit, and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. One or more retention elements are provided on the frame for retaining the frame within the uterus of a female mammal.
