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MONOSEBACATE OF PYRAZOLE DERIVATIVE
专利权人:
发明人:
타케우치, 히데키,츠루, 에이지
申请号:
KR1020107014837
公开号:
KR1014165610000B1
申请日:
2008.12.24
申请国别(地区):
KR
年份:
2014
代理人:
摘要:
The present invention provides a novel form of 3-(3-{4-[3-(²-D-gluco-pyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide with improved storage stability. Since bis[3-(3-{4-[3-( - D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}pr opylamino)-2,2-dimethylpropionamide] monosebacate has extremely excellent storage stability, it is useful as a drug substance. Furthermore, it shows an extremely good crystalline property and can be purified by a convenient method, and therefore is suitable for the industrial preparation.본 발명은 3-(3-{4-[3-(β-D-글루코피라노실옥시)-5-이소프로필-1H-피라졸-4-일메틸]-3-메틸페녹시}프로필아미노)-2,2-디메틸프로피온아미드의 보존안정성이 개량된 신규형태를 제공한다. 비스[3-(3-{4-[3-(β-D-글루코피라노실옥시)-5-이소프로필-1H-피라졸-4-일메틸]-3-메틸페녹시}프로필아미노)-2,2-디메틸프로피온아미드]·모노세박산염은 극히 우수한 보존안정성을 가지므로, 의약품 원체로서 유용하다. 게다가, 극히 양호한 결정성을 보이며, 간편한 방법에 의해 정제가 가능하기 때문에, 공업적 생산에 적합하다.
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中国工程科技知识中心
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