ANIL VASUDEVAN,BRYAN K. SORENSEN,CHRIS TSE,HELMUT MACK,HOWARD R. HEYMAN,KEVIN R. WOLLER,MARINA A. PLIUSHCHEV,MICHAEL L. CURTIN,MICHAEL MICHAELIDES,OMAR J. SHAH,RAMZI SWEIS,RICHARD F. CLARK,TODD .M HAN
申请号：
BR112013012078
公开号：
BR112013012078A2
申请日:
2011.11.11
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of using the compounds to treat diseases during which NAMPT is expressed, e.g., cancer, metabolic disorders, and inflammatory disorders. Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of using the compounds to treat diseases during which ROCK is expressed, e.g., cancer, cardiovascular disorders, and inflammatory disorders.
