Emory University;The United State Government as Represented by the Department of Veterans Affairs
发明人:
Jing Chen,Jack Arbiser,Brian Pollack,Siyuan Xia
申请号：
US16386763
公开号：
US20200000764A1
申请日:
2019.04.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or other agents that antagonize acetoacetate-BRAF V600 mutant binding to attenuate BRAF V600 mutant tumor growth. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of an agent to a subject in need thereof, wherein the agent is dehydroacetic acid, derivative, prodrug, or salt thereof.
