The present invention relates to a composition, especially in gel form, comprising at least one grapefruit seed extract, at least one lady's mantle leaf extract, at least one stevia extract, and at least curcumin. The invention also relates to said composition in the form of a medical device or of a cosmetic composition, and to the use thereof for the treatment of complaints of the buccal cavity. Moreover, the invention also pertains to the use of the composition for its analgesic activity. The invention also relates to the use of said composition for preserving the resident flora of the buccal cavity.