PROBLEM TO BE SOLVED: To provide a method for inhibiting activity of matrix metalloproteinase in the skin.SOLUTION: A method of inhibiting activity of matrix metalloproteinase in the skin comprises topically applying to a skin surface a composition comprising an amount of hydroxamic acid, its salts and/or complexes and an amount of glycol in a synergistically effective proportion. A method of inhibiting or mitigating expression of aging in a skin surface comprises topically applying to a skin surface a composition comprising an amount of hydroxamic acid, its salts and/or complexes and an amount of glycol in a synergistically effective proportion.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】皮膚におけるマトリックスメタロプロテイナーゼの活性を阻害する方法の提供。【解決手段】相乗的に有効な比率のヒドロキサム酸、その塩及び/又は錯体の量と、グリコールの量とを含む組成物を皮膚表面へと局所適用することを含む、皮膚におけるマトリックスメタロプロテイナーゼの活性を阻害する方法。また、相乗的に有効な比率のヒドロキサム酸、その塩及び/又は錯体の量と、グリコールの量とを含む組成物を皮膚表面へと局所適用することを含む、皮膚表面の老化の出現を抑制又は軽減する方法。【選択図】なし
