LEE, GWAN SUN,KWON, SE CHANG,JUNG, SUNG YOUB,KANG, EUN HAE,PARK, YOUNG JIN,KIM, MIN YOUNG,SONG, DAE HAE
申请号：
ARP170101541
公开号：
AR108767A2
申请日:
2017.06.06
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a composition for the treatment of Obesity related diseases which are selected from the group consisting of hyperlipidemiaGastroesophageal reflux related.Obesity and Hypercholesterolemia, steatohepatitis,Characterized in that it comprises an insulinotropic Peptide conjugate in which an insulinotropic Peptide is linked to an immunoglobulin FC region, not by a Linker peptid\u00edlico,Selected from the group consisting of SMCC (Succinimidyl - 4 - (N - methyl - 1 - maleimido) ciclohexan - SFB (carboxylate) - 4 - formilbenzoato Succinimidyl), Polyethylene glycol, Polypropylene glycol,Polyvinylpyrrolidone, copolymers of ethylene glycol and propylene glycol, Polyols polioxietilados, polyvinyl alcohol, polyvinyl etil\u00e9ter polysaccharide, dextran, biodegradable Polymers,Such as Pla (polylactic acid, polylactic acid) and PLGA (polylactic - Glycolic Acid, polylactic - Glycolic Acid) Polymer Chitin, LipidHyaluronic acid and combinations thereof and wherein the insulinotropic Peptide selected from the group consisting of: B - hydroxy - imidazopropionil exendin-4,In which the n-terminal amino Group of exendin-4 is substituted with a hydroxyl Group, Carboxy - B - imidazopropionil exendin-4,In which the n-terminal amino Group of exendin-4 is replaced with a carboxyl Group, Dimethyl histidyl exendin-4,In which the n-terminal amino Group of exendin-4 is modified with two Methyl groups and imidazo - acetyl exendin-4,In which the Alpha carbon of the histidine residue in n-terminus of exendin-4 has been eliminated.Reivindicación 1: Una composición para el tratamiento de las enfermedades relacionadas con la obesidad las cuales se seleccionan del grupo que consiste en hiperlipidemia, reflujo gastroesofágico relacionado con la. obesidad, esteatohepatitis e hipercolesterolemia, caracterizada porque comprende un conjugado de péptido insulinotrópico en el cual un péptido insulinotrópico está unido a una región Fc de la inmunoglobulina, mediante un enlazador no peptidílico, selecc
