Arnold Melman,Kelvin Davies,David Spray,Yi Wang,Joel Friedman,Mahantash Nadavi
申请号：
US14910176
公开号：
US20160184455A1
申请日:
2014.08.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides compositions and methods to improve one or more signs or symptoms of smooth muscle diseases. Compositions of the disclosure may include a plasmid vector containing a variant nucleic that encodes for a variant amino acid sequence of the alpha subunit of the BK potassium channel. Compositions may further include a nanoparticle delivery system. Compositions and methods of use of the disclosure may be used to treat, for example, over active bladder (OAB) syndrome and erectile dysfunction (ED).
