It is intended to provide a preventive or remedy for integration dysfunction syndrome by which integration dysfunction syndrome, in particular, positive symptoms thereof, can be treated without inducing information-processing disorder relating to cognition disorder, i.e., one of the syndromes of integration dysfunction syndrome. Thus, a preventive or remedy for integration dysfunction syndrome, which comprises as the active ingredient a compound having a specific morphinane skeleton typified by the following compound 1 or a pharmacologically acceptable acid addition salt thereof, is provided.
