Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)

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专利权人:

UNIVERSITE PARIS DIDEROT—PARIS 7;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

发明人:

Nathalie Vergnolle,Jean-Michel Sallenave,Philippe Langella,Luis Bermudez-Humaran

申请号：

US14490161

公开号：

US09688742B2

申请日:

2014.09.18

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.

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