BACTERIES PROBIOTIQUES RECOMBINANTES POUR LA PREVENTION ET LE TRAITEMENT DU SYNDROME ABDOMINAL INFLAMMATOIRE (IBD) ET DU SYNDROME DU COLON IRRITABLE (IBS)
UNIVERSITE PARIS DIDEROT - PARIS 7;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA);INSTITUT PASTEUR
发明人:
VERGNOLLE, NATHALIE,SALLENAVE, JEAN-MICHEL,LANGELLA, PHILIPPE,BERMUDEZ-HUMARAN, LUIS
申请号：
CA2786847
公开号：
CA2786847C
申请日:
2011.01.14
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction of the trappin-2 protein, a member of the WAP family proteins or an active fraction of a member of the WAP family proteins or a member of the Serpin family proteins or an active fraction of a member of the Serpin family proteins for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction of the trappin-2 protein, a gene coding for a member of the WAP family proteins or an active fraction of a member of the WAP family proteins, or a gene coding for a member of the serpin family proteins or an active fraction of a member of the serpin family proteins.
