THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人:
RITTENHOUSE-OLSON, KATE,ABDULLAH, JULIA,ENG, JING YING,KOURY, STEPHEN T.
申请号：
CA2943681
公开号：
CA2943681A1
申请日:
2015.04.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Provided are humanized monoclonal antibodies (mAbs) or fragments thereof that bind with specificity to the Thomsen-Friedenreich (TF) human tumor antigen. Three distinct variable heavy and three variable light chains are provided, and can be combined to make a total of twenty-five distinct heavy and light chain combinations. Methods of using the mAbs and fragments thereof for cancer therapy and diagnostic imaging are provided, as are methods for making the mAbs and fragments thereof. In vitro cell cultures that express the mAbs and fragments thereof, and kits are also provided.
