The present invention is 5,8- dimethoxy -1,4 -naphthoquinone ( 5,8 Dimethxy-1,4-naphthoquinone, DMNQ) of the derivative of 2-substituted -5,8 -dimethoxy -1,4- naphthoquinone (2-substituted-5,8-dimethoxy-1,4-naphthoquinone) in compound the compounds may be useful in the prevention and composition for the treatment of cardiovascular disease by inhibiting the PDGF (platelet derived growth factor, PDGF) relates .본 발명은 5,8-디메톡시-1,4-나프토퀴논 (5,8-Dimethxy-1,4-naphthoquinone, DMNQ) 의 유도체인 2-치환-5,8-디메톡시-1,4-나프토퀴논(2-substituted-5,8-dimethoxy-1,4-naphthoquinone) 화합물에 관한 것으로 상기 화합물은 혈소판 유래 성장인자(platelet derived growth factor, PDGF)를 억제함으로써 심혈관 질환의 예방 및 치료용 조성물로 유용하게 이용될 수 있다.
