Ezio BONVINI;Leslie S. JOHNSON;Paul A. MOORE;Kalpana SHAH;MACROGENICS INC.;Douglas H. SMITH;ROSS LA MOTTE-MOHS;SCOTT KOENIG
发明人:
ROSS LA MOTTE-MOHS,SCOTT KOENIG,Leslie S. JOHNSON,Kalpana SHAH,Ezio BONVINI,Paul A. MOORE,Douglas H. SMITH
申请号：
IL25721618
公开号：
IL257216D0
申请日:
2018.01.29
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and to human PD-1: PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14, or PD-1 mAb 15, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD-1-binding molecules that comprise PD-1 binding fragments of such anti-PD-1 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such PD-1-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of using molecules that bind PD-1 for stimulating immune responses, as well as methods of detecting PD-1.
