A NOVEL PROCESS FOR RALOXIFENE HYDROCHLORIDE

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专利权人:

发明人:

GURJAR MUKUND KESHAV,DESHMUKH SANJAY SHANKAR,HIVAREKAR RAGHVENDRA RAMESHRAO,HINGMIRE VAIBHAV SHIVAJI,HONPARKHE RAMCHANDRA BIRAPPA,MEHTA SAMIT SATISH

申请号：

IN2845/MUM/2014

公开号：

IN2014MU02845A

申请日:

2014.09.05

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The present invention provides a novel process for preparation of Raloxifene hydrochloride (Ia) comprising reaction of 2-(4- hydroxyphenyl) benzo [b] thiophene of formula (II) with 4-[2-(l-piperidinyl)-ethoxy]-phenyl] benzoic acid (III) using Eatons reagent. The resulting compound, 6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)-3-[4-(2-piperidinoethoxy) benzoyl]benzo[b]thiophene of formula (III), after deprotection of the methanesulfonyl groups, and treatment with hydrochloric acid yields Raloxifene hydrochloride of formula (Ia) having desired purity..

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