Anti-TrkA antibodies and derivatives thereof

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专利权人:

Lay Line Genomics S.p.A.

发明人:

Benigni, Fabio,D'Ambrosio, Daniele,DAmbrosio, Daniele

申请号：

AU2009211340

公开号：

AU2009211340B2

申请日:

2009.02.04

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

An anti-TrkA antibody is provided that comprises: a) a variable heavy chain comprising a sequence selected fromany of BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5, or HuVHWOv as shown in Figure (1a)； or from variants of any of said sequences and/or b) a variable light chain comprising a sequence selected from any of BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 or BXhVL8； as shown in Figure (1b), or from variants of any of said sequences.TrkA-binding derivatives are also provided. Antibodies or derivatives of the present invention are useful in a number of therapies, including pain therapy.

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