Anti-TRKA antibodies and derivatives thereof

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专利权人:

LAY LINE GENOMICS SPA

发明人:

BENIGNI FABIO,D'AMBROSIO DANIELE

申请号：

AP2010005379

公开号：

AP2929A

申请日:

2009.02.04

申请国别(地区):

AP

年份:

2014

代理人:

摘要：

An anti-TrkA antibody is provided that comprises: a) a variable heavy chain comprising a sequence selected from any of BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5, or HuVHWOv as shown in FIG. 1a； or from variants of any of said sequences and/or b) a variable light chain comprising a sequence selected from any of BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 or BXhVL8； as shown in FIG. 1b, or from variants of any of said sequences. TrkA-binding derivatives are also provided. Antibodies or derivatives of the present invention are useful in a number of therapies, including pain therapy.

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