A biopsy device for insertion to a target site within a living body comprises a first longitudinal element including a first longitudinal element extending from a first element proximal end to a tissue piercing first element distal end and, the first longitudinal element defining a first lumen extending therethrough from a proximal opening at the first element proximal end to a distal opening at the first element distal end. The first longitudinal element is sufficiently flexible to be inserted to a target site along a tortuous path within a natural body lumen and a second longitudinal element extending from a proximal end to a tissue piercing second element distal end. The second longitudinal element is sized to be slidably received in the first lumen and defining a second lumen extending therewithin to a tissue receiving opening at the second element distal end. The second longitudinal element is sufficiently flexible to be inserted to a target site along a tortuous path within a natural body lumen.
