A kind of sampling device for biopsy, including handle and flexible sleeve are from handle. The flexible sleeve includes: inner catheter, limits the sidewall surfaces of opening, and further limits central chamber and opening Outer catheter and moveable surround are located relative to inner conduit With the outer catheter of cutting element distal end. The flexible sleeve be configured so that vacuum can be applied through inner conduit center generate suction that extract sheet of tissue occur being limited to interior conduit. It is mobile relative to outer conduit that the handle is configured as inner conduit, so that it is that those have introducing opening that tissue block is cut and cut off to cutting element.