#$%^&*AU2013203959A120130509.pdf#####CkNRFPobI\DCC\SCG4249I-..I.D OC./ A412 ABSTRACT The present invention includes use of a biological response modifier (BRM) to modulate an immune response in a subject while avoiding or limiting common side-effects associate with BRM use. The BRMs of the present invention can be injected into a secondary lymphatic organ of the subject or into an area of relatively high drainage into a secondary lymphatic organ of the subject. The modulated immune response can be general or antigen-specific.