An endoscopic surgical clip applier (10) includes a handle assembly (100) configured to releasably engage at least two different endoscopic assemblies (200,300). The handle assembly (100) is configured to transition from a non-ratcheting use condition to a ratcheting use condition when an endoscopic assembly (200,300) configured for ratcheting use is engaged with the handle assembly (100). The handle assembly (100) is maintained in the non-ratcheting use condition when an endoscopic assembly (200,300) configured for non-ratcheting use is engaged with the handle assembly (100). Endoscopic assemblies (200,300) for use with the handle assembly are also provided.