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1,2-DIHYDRO-2-OXOQUINOLINE COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS
专利权人:
SUVEN LIFE SCIENCES LIMITED
发明人:
NIROGI, RAMAKRISHNA,MOHAMMED, ABDUL, RASHEED,AHMAD, ISHTIYAQUE,JAYARAJAN, PRADEEP,KANDIKERE, NAGARAJ, VISHWOTTAM,SHINDE, ANIL, KARBHARI,KAMBHAMPATI, RAMA, SASTRI,BHYRAPUNENI, GOPINADH,RAVULA, JYOTHSNA
申请号:
NZ59850509
公开号:
NZ598505A
申请日:
2009.12.29
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
The present disclosure relates to 1,2-dihydro-2-oxoquinoline compounds of the formula (I), and compositions containing them. There is also disclosed a process for the preparation of above said novel compounds, and compositions containing them. The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity. Some examples of the disclosed compounds are: N-[(5-Phenyl-2-azatricyclo[3.3 ,1,13,7]dec-2-yl) propyl]-4-hydroxy-1-isopropyl-2-oxo-1 ,2-dihydroquinoline-3-carboxamide hydrochloride N-(1-Butyl piperidin-4-yl)-4-hydroxy-1-isopropyl-2-oxo-1,2-dihydroquinoline-3 carboxamide hydrochloride and N-(4-(Pyrrolidin-1-yl) cyclohexyl)-4-hydroxy-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxamide hydrochloride.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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