THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人:
CASTRACANE, James,RAJA, Waseem Khan
申请号：
USUS2010/057400
公开号：
WO2011/063218A9
申请日:
2010.11.19
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
A cell collecting device (10, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 170) having a housing (12) with an inlet (16, 56, 66, 76, 86, 96, 106, 116, 126, 136, 146, 176) for receiving cells, a cell attractant cavity (14, 54, 64, 74, 84, 94, 104, 114, 124, 134, 144, 174) have a cell attractant, a cell collection channel (18, 58, 68, 78, 88, 98, 108, 118, 128, 138, 148, 178) running from the inlet to the cell attractant cavity, and a plurality of electrodes (20) positioned to detect the presence of cells is disclosed. The cell attractant cavity may include a porous medium (29, 59, 69, 79, 89, 99, 119, 129, 139, 149, 179A, 179B), such as, a hydrogel, containing the cell attractant, such as, epidermal growth factor. The channel may include a plurality of restrictions (93, 113, 123, 143, 173) and expansions or chambers (115, 125, 135, 145, 175) to assist in maintaining the porous medium while permitting the passage of attractant and cells. The device may be implanted into a patient for an extended period of time, and then removed and examined. A method for collecting cells, an implantable attractant dispersing device, and a porous medium for controlled releasing of a compound are also disclosed.La présente invention concerne un dispositif de collecte de cellules (10, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 170) ayant un logement (12) avec un orifice dentrée (16, 56, 66, 76, 86, 96, 106, 116, 126, 136, 146, 176) pour la réception de cellules, une cavité attirant les cellules (14, 54, 64, 74, 84, 94, 104, 114, 124, 134, 144, 174) ayant un attracteur de cellules, un canal de collecte de cellules (18, 58, 68, 78, 88, 98, 108, 118, 128, 138, 148, 178) sétendant de lorifice dentrée jusquà la cavité attirant les cellules, et une pluralité délectrodes (20) positionnées pour détecter la présence de cellules. La cavité attirant les cellules peut comprendre un milieu poreux (29, 59, 69, 79, 89, 99, 119, 129, 139, 149, 179A, 179B), tel quun hydrogel, contenant lattract
