Brian Christopher Bales,Brian James Grimmond,Daniel Eugene Meyer,Bruce Allan Hay,Michael Todd Luttrell
申请号：
US13538493
公开号：
US09251937B2
申请日:
2012.06.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
