Elmar Kraus,Christoph Bruecher,Benjamin Daelken,Matthias Germer,Steffen Zeng,Frank Osterroth,Christoph Uherek,Silke Aigner,Gregor Schulz
申请号：
US12342285
公开号：
US09221914B2
申请日:
2008.12.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is a human murine chimeric antibody targeting CD138 which substantially retains the antigen binding region of its murine counterpart. The engineered antibody displays improved binding affinities to the antigen and/or more homogenous binding to target cells relative to its murine counterpart. A constant region of the immunoglobulin heavy chain is preferably an IgG4 isotype constant region.
